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Original Articles
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- The Modified Ferriman-Gallwey Score and Hirsutism among Filipino Women
- Ma. Karen Celine C. Ilagan, Elizabeth Paz-Pacheco, Darwin Z. Totesora, Lyra Ruth Clemente-Chua, Jundelle Romulo K. Jalique
- Endocrinol Metab. 2019;34(4):374-381. Published online December 23, 2019
- DOI: https://doi.org/10.3803/EnM.2019.34.4.374
- 7,985 View
- 170 Download
- 18 Web of Science
- 18 Crossref
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Abstract
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ePub Background The modified Ferriman-Gallwey (mFG) score is the gold standard for the clinical evaluation of hirsutism. However, racial variations in terminal hair growth limit this tool. This study aimed to determine the mFG cut-off score among Filipino women and its association with biochemical hyperandrogenism.
Methods A total of 128 Filipino women were included in this prospective cross-sectional study and were divided into two groups: a polycystic ovary syndrome (PCOS) group (
n =28) and a non-PCOS group (n =100). The participants underwent mFG score determination, ovarian ultrasound conducted by a single sonographer, and hormone testing. The mFG cut-off score was determined based on the 95th percentile of the non-PCOS group. Logistic regression was used to analyze the relationship between mFG score and biochemical hyperandrogenism.Results Although the mFG score was generally low in both the PCOS and non-PCOS groups, the former exhibited a higher mean score than the latter (4.3±3.0 vs. 2.0±2.2,
P <0.001). Normal values for the total mFG score ranged from 0 to 7. Using a cut-off score of 7, a higher proportion of hirsute women (mFG score ≥7) was observed in the PCOS group versus the non-PCOS group (17.9% vs. 5.0%,P =0.025). Elevated calculated free testosterone (FT) was also found to be significantly associated with hirsutism (odds ratio, 6.2; 95% confidence interval, 1.2 to 32.4 pmol/L;P =0.030).Conclusion A score of 7 and above constitutes hirsutism in this population of Filipino women. Hirsute women are more likely than non-hirsute women to have elevated calculated FT.
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Citations
Citations to this article as recorded by
- Understanding hirsutism in PCOS
Talita Fischer Oliveira, Fabio Vasconcellos Comim
Expert Review of Endocrinology & Metabolism.2024; 19(2): 103. CrossRef - Correlation of Body Mass Index with Anthropometric and Biochemical Parameters Among Polycystic Ovary Syndrome Phenotypes
Tanuja Mehra, Sonali Sharma, Tasneem Zahra, Sapna Jangir, Barkha Gupta
Indian Journal of Clinical Biochemistry.2023; 38(2): 231. CrossRef - Predictive factors of Sexual Quality of Life in women with polycystic ovary syndrome: a path analysis
Azam Maleki, Ensiyeh Jenabi, Bita Fereidooni, Sara Abdoli
International Journal of Impotence Research.2023; 35(8): 748. CrossRef - Free-androgen Index in Women with Polycystic Ovarian Syndrome: A Meta-Analysis
Prakash Patil, Neevan D'Souza, Sudeep D. Ghate, Lakshmi Nagendra, Harish B. Girijashankar
Journal of Health and Allied Sciences NU.2023; 13(03): 380. CrossRef - Association of free testosterone, glucose level and obesity among women with polycystic ovary syndrome in Soran city, Kurdistan-Iraq
P.J. Jalil, B.H. Shnawa, M.H. Ahmed
Clínica e Investigación en Ginecología y Obstetricia.2023; 50(4): 100903. CrossRef - Questioning PCOS phenotypes for reclassification and tailored therapy
Samuel Harry Myers, Michele Russo, Simona Dinicola, Gianpiero Forte, Vittorio Unfer
Trends in Endocrinology & Metabolism.2023; 34(11): 694. CrossRef - Clinical and Biochemical Evaluation of Hirsutism in Young, Lean Girls from Kirkuk City, Iraq: A Cross-Sectional Study
Razaw Omar Ibrahim, Najlaa Kadhim Ali, Iqbal Sameen Ali
Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2023; 5(1S): S51. CrossRef - Current and future perspectives on clinical management of classic 21-hydroxylase deficiency
Analia Yogi, Kenichi Kashimada
Endocrine Journal.2023; 70(10): 945. CrossRef - Effect of Berberine Phytosome on reproductive, dermatologic, and metabolic characteristics in women with polycystic ovary syndrome: a controlled, randomized, multi-centric, open-label clinical trial
Francesco Di Pierro, Ruqqia Sultana, Amna Zia Eusaph, Saida Abrar, Mahroo Bugti, Fauzia Afridi, Umer Farooq, Somia Iqtadar, Fareeha Ghauri, Syeda Makhduma, Shazia Nourin, Ayesha Kanwal, Aasiya Bano, Ali Akbar Bugti, Shah Mureed, Ayesha Ghazal, Romana Irsh
Frontiers in Pharmacology.2023;[Epub] CrossRef - Is There a Difference in Hirsutism Score in Adolescents with Polycystic Ovary Syndrome on the Basis of Ethnicity and Race?
Fatmaelzahraa Badr, Asma Javed Chattha
Journal of Pediatric and Adolescent Gynecology.2023;[Epub] CrossRef - A Body-Neutral and Gender-Neutral Modified Ferriman–Gallwey Diagram
Frances Grimstad, Quentin Moyer, Coleen R. Williams, Jessica Kremen
Journal of Pediatric and Adolescent Gynecology.2022; 35(3): 375. CrossRef - Assessment of clinical, biochemical, and hormonal profile of lean versus overweight polycystic ovarian syndrome patients: A cross-sectional study
Vikrant Ghatnatti, Shwetha Patil, Harpreet Kour
APIK Journal of Internal Medicine.2022; 10(1): 13. CrossRef - Regional variability of modified Ferriman-Gallwey scorring in premenopausal healthy women in Southern Turkey
Gurgun Tugce Vural Solak, Gamze Akkus, Yavuzalp Solak, Sevgul Kose, Murat Sert
Gynecological Endocrinology.2022; 38(8): 666. CrossRef - Detection of pure Leydig cell ovarian tumor not visible on imaging by selective venous blood sampling in a woman with secondary amenorrhea and hirsutism: A case report
Aki Oride, Haruhiko Kanasaki, Hiroe Okada, Satoru Kyo
Case Reports in Women's Health.2021; 30: e00298. CrossRef - Giant androgen-producing adrenocortical carcinoma with atrial flutter: A case report and review of the literature
Mircea-Florin Costache, Raluca-Elena Arhirii, Simona-Juliette Mogos, Corina Lupascu-Ursulescu, Cezara-Ioana Litcanu, Adi-Ionut Ciumanghel, Catalina Cucu, Cristina-Mihaela Ghiciuc, Antoniu-Octavian Petris, Nicolae Danila
World Journal of Clinical Cases.2021; 9(20): 5575. CrossRef - The effect of low glycemic index diet on the reproductive and clinical profile in women with polycystic ovarian syndrome: A systematic review and meta-analysis
Najmieh Saadati, Fatemeh Haidari, Mojgan Barati, Roshan Nikbakht, Golshan Mirmomeni, Fakher Rahim
Heliyon.2021; 7(11): e08338. CrossRef - The role of high serum uric acid levels in androgenic and non-androgenic polycystic ovarian syndrome patients
Ranakishor Pelluri, Kongara Srikanth, Harika Paritala, Vamsi Ravi, Sri Pandu Mukharjee Kamma, Kishan Dravid Piduguralla, Unnam Venkateswarlu, Jalasuthram Subrahmanyam, Kiranmayee Bannaravuri, Thanmayee Thunga, Ragini Vemparala, Sruthi Doddapaneni, Naresh
Clinical Epidemiology and Global Health.2021; 12: 100910. CrossRef - Testosterone or Dehydroepiandrosterone Sulfate as a Biomarker for Hirsutism in Women with Polycystic Ovary Syndrome
Husam Jihad Imran, Samer Abdulameer Dhaher, Abbas Ali Mansour
Biomedical and Pharmacology Journal.2020; 13(4): 1815. CrossRef
- Understanding hirsutism in PCOS
- Thyroid
- Anaplastic Thyroid Cancer: Experience of the Philippine General Hospital
- Tom Edward Lo, Cecilia Alegado Jimeno, Elizabeth Paz-Pacheco
- Endocrinol Metab. 2015;30(2):195-200. Published online June 30, 2015
- DOI: https://doi.org/10.3803/EnM.2015.30.2.195
- 3,430 View
- 42 Download
- 4 Web of Science
- 4 Crossref
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Abstract
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Background Anaplastic thyroid cancer (ATC) is a rare type of thyroid malignancy and one of the most aggressive solid tumors, responsible for between 14% and 50% of the total annual mortality associated with thyroid cancer.
Methods A retrospective study was made of all ATC cases diagnosed by biopsy in the Philippine General Hospital between 2008 and 2013.
Results A total of 15 patients were identified, with a median age at diagnosis of 63 years. All tumors were at least 6 cm in size upon diagnosis. All patients had a previous history of thyroid pathology, presenting with an average duration of 11 years. Eleven patients presented with cervical lymphadenopathies, whereas seven exhibited signs of distant metastases, for which the lungs appeared to be the most common site. More than 70% of the patients presented with a rapidly growing neck mass, leading to airway obstruction. Only three patients were treated using curative surgery; the majority received palliative and supportive forms of treatment. In addition, only three patients were offered radiotherapy. Chemotherapy was not offered to any patient. Only two patients were confirmed to still be alive during the study period. The median survival time for the other patients was 3 months; in the majority of cases the patient died within the first year following diagnosis.
Conclusion Our experience with ATC demonstrated concordance with other institutions with respect to current clinical profile, presentation, and prognosis. An absence of distant metastases and lymph node involvement was associated with improved survival outcomes, whereas age at diagnosis and tumor size did not affect survival. Curative surgery offers the most effective means of prolonging survival. Radiotherapy and chemotherapy in combination with surgery represents a promising treatment strategy.
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Citations
Citations to this article as recorded by- Prior Thyroid and Nonthyroid Cancer History Do Not Significantly Alter Overall Survival in Patients Diagnosed with Anaplastic Thyroid Cancer
Yu Han Chen, Maria Cabanillas, Jared Sperling, Li Xu, Maitrayee Goswami, Anastasios Maniakas, Michelle D. Williams, Stephen Y. Lai, Naifa Busaidy, Ramona Dadu, Mark E. Zafereo, Jennifer Rui Wang
Thyroid.2023; 33(3): 321. CrossRef - Clinical Outcome and Toxicity in the Treatment of Anaplastic Thyroid Cancer in Elderly Patients
Teresa Augustin, Dmytro Oliinyk, Viktoria Florentine Koehler, Josefine Rauch, Claus Belka, Christine Spitzweg, Lukas Käsmann
Journal of Clinical Medicine.2020; 9(10): 3231. CrossRef - Poorly Differentiated Thyroid Carcinoma: 10-Year Experience in a Southeast Asian Population
Marc Gregory Yu, Jonathan Rivera, Cecilia Jimeno
Endocrinology and Metabolism.2017; 32(2): 288. CrossRef - Macrophage Densities Correlated with CXC Chemokine Receptor 4 Expression and Related with Poor Survival in Anaplastic Thyroid Cancer
Dae In Kim, Eunyoung Kim, Young A Kim, Sun Wook Cho, Jung Ah Lim, Young Joo Park
Endocrinology and Metabolism.2016; 31(3): 469. CrossRef
- Prior Thyroid and Nonthyroid Cancer History Do Not Significantly Alter Overall Survival in Patients Diagnosed with Anaplastic Thyroid Cancer
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